2021

Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike

Tong P, Gautam A, Windsor IW, Travers M, Chen Y, Garcia N, Whiteman NB, McKay LGA, Storm N, Malsick LE, Honko AN, Lelis FJN, Habibi S, Jenni S, Cai Y, Rennick LJ, Duprex WP, McCarthy KR, Lavine CL, Zuo T, Lin J, Zuiani A, Feldman J, MacDonald EA, Hauser BM, Griffths A, Seaman MS, Schmidt AG, Chen B, Neuberg D, Bajic G, Harrison SC, Wesemann DR.Cell. 2021 Sep 16;184(19):4969-4980.e15. doi: 10.1016/j.cell.2021.07.025. Epub 2021 Jul 23.PMID: 34332650 PMCID:  PMC8299219

A Prevalent Focused Human Antibody Response to the Influenza Virus Hemagglutinin Head Interface

McCarthy KR, Lee J, Watanabe A, Kuraoka M, Robinson-McCarthy LR, Georgiou G, Kelsoe G, Harrison SC. mBio. 2021. 12(3):e0114421. doi: 10.1128/mBio.01144-21. PMID: 34060327 PMCID: PMC8262862

Differential immune imprinting by influenza virus vaccination and infection in nonhuman primates

McCarthy KR, Von Holle TA, Sutherland LL, Oguin TH, Sempowski GD, Harrison SC, Moody MA. PNAS. 2021. 118(23):e2026752118. PMID: 34074774 PMCID: PMC8201799 DOI: 10.1073/pnas.2026752118

Deletion disrupts a conserved antibody epitope in a SARS-CoV-2 variant of concern

Rennick LJ, Robinson-McCarthy LR, Nambulli S, Duprex WO, McCarthy KR. bioRxiv. 2021. doi: 10.1101/2021.03.05.434168

Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape.

McCarthy KR* , Rennick LJ, Nambulli S, Robinson-McCarthy LR, Bain WG, Haidar G, Duprex WP*. Science. 2021;371:1139-1142 10.1126/science.abf6950. PMID: 33536258 *Co-corresponding

2020 & Prior

A prevalent focused human antibody response to the influenza hemagglutinin head interface

McCarthy KR, Lee J, Watanabe A, Kuraoka M, Robinson-McCarthy LR, Georgiou G, Kelsoe G, Harrison SC. bioRxiv. 2020:2020.12.28.424595. doi: 10.1101/2020.12.28.424595.

Structure of the Receptor Binding Domain of EnvP(b)1, an Endogenous Retroviral Envelope Protein Expressed in Human Tissues

McCarthy KR*, Timpona JL*, Jenni S, Bloyet LM, Brusic V, Johnson WE, Whelan SPJ, Robinson-McCarthy LR. Structure of the Receptor Binding Domain of EnvP(b)1, an Endogenous Retroviral Envelope Protein Expressed in Human Tissues. mBio. 2020;11(6). Epub 2020/11/19. doi: 10.1128/mBio.02772-20. PubMed PMID: 33203760; PMCID: PMC7683403. *Co-first authors

Affinity maturation in a human humoral response to influenza hemagglutinin.

McCarthy KR, Raymond DD, Do KT, Schmidt AG, Harrison SC.  Proc Natl Acad Sci U S A. 2019. Epub 2019/12/18. doi: 10.1073/pnas.1915620116. PubMed PMID: 31843892; PMCID: PMC6936356.

Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope.

Bajic G, Maron MJ, Adachi Y, Onodera T, McCarthy KR, McGee CE, Sempowski GD, Takahashi Y, Kelsoe G, Kuraoka M, Schmidt AG. Cell Host Microbe. 2019;25(6):827-35 e6. Epub 2019/05/21. doi: 10.1016/j.chom.2019.04.003. PubMed PMID: 31104946; PMCID: PMC6748655.

Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism.

Watanabe A*, McCarthy KR*, Kuraoka M, Schmidt AG, Adachi Y, Onodera T, Tonouchi K, Caradonna TM, Bajic G, Song S, McGee CE, Sempowski GD, Feng F, Urick P, Kepler TB, Takahashi Y, Harrison SC, Kelsoe G. Cell. 2019;177(5):1124-35 e16. Epub 2019/05/18. doi: 10.1016/j.cell.2019.03.048. PubMed PMID: 31100267; PMCID: PMC6825805. *Co-first author

Reconstruction of the cell entry pathway of an extinct virus.

Robinson-McCarthy LR, McCarthy KR, Raaben M, Piccinotti S, Nieuwenhuis J, Stubbs SH, Bakkers MJG, Whelan SPJ. PLoS Pathog. 2018;14(8):e1007123. Epub 2018/08/07. doi: 10.1371/journal.ppat.1007123. PubMed PMID: 30080900; PMCID: PMC6095630.

Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires

McCarthy KR*, Watanabe A*, Kuraoka M, Do KT, McGee CE, Sempowski GD, Kepler TB, Schmidt AG, Kelsoe G, Harrison SC. Immunity. 2018;48(1):174-84 e9. Epub 2018/01/19. doi: 10.1016/j.immuni.2017.12.009. PubMed PMID: 29343437; PMCID: PMC5810956. Co-first authors

Immunogenic Stimulus for Germline Precursors of Antibodies that Engage the Influenza Hemagglutinin Receptor-Binding Site.

Schmidt AG, Do KT, McCarthy KR, Kepler TB, Liao HX, Moody MA, Haynes BF, Harrison SC. Cell Rep. 2015;13(12):2842-50. Epub 2015/12/30. doi: 10.1016/j.celrep.2015.11.063. PubMed PMID: 26711348; PMCID: PMC4698027.

History of the Lost SIV from Crab-Eating Macaques: SIVmfa.

McCarthy KR, Johnson WE, Kirmaier A.PLoS One. 2016;11(7):e0159281. Epub 2016/07/16. doi: 10.1371/journal.pone.0159281. PubMed PMID: 27415779; PMCID: PMC4944941.

Evolutionary and Functional Analysis of Old World Primate TRIM5 Reveals the Ancient Emergence of Primate Lentiviruses and Convergent Evolution Targeting a Conserved Capsid Interface

McCarthy KR, Kirmaier A, Autissier P, Johnson WE. PLoS Pathog. 2015;11(8):e1005085. Epub 2015/08/21. doi: 10.1371/journal.ppat.1005085. PubMed PMID: 26291613; PMCID: PMC4546234.

Plastic proteins and monkey blocks: how lentiviruses evolved to replicate in the presence of primate restriction factors.

McCarthy KR, Johnson WE. PLoS Pathog. 2014;10(4):e1004017. Epub 2014/04/20. doi: 10.1371/journal.ppat.1004017. PubMed PMID: 24743473; PMCID: PMC3990706.

APOBEC3G polymorphism as a selective barrier to cross-species transmission and emergence of pathogenic SIV and AIDS in a primate host.

Krupp A, McCarthy KR, Ooms M, Letko M, Morgan JS, Simon V, Johnson WE. PLoS Pathog. 2013;9(10):e1003641. Epub 2013/10/08. doi: 10.1371/journal.ppat.1003641. PubMed PMID: 24098115; PMCID: PMC3789815.

Gain-of-sensitivity mutations in a Trim5-resistant primary isolate of pathogenic SIV identify two independent conserved determinants of Trim5alpha specificity.

McCarthy KR, Schmidt AG, Kirmaier A, Wyand AL, Newman RM, Johnson WE. PLoS Pathog. 2013;9(5):e1003352. Epub 2013/05/16. doi: 10.1371/journal.ppat.1003352. PubMed PMID: 23675300; PMCID: PMC3649984.